GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11051970 | 1 | rs11051970 | chr12:32537488 | FGD4 | chr12:32638906-32798982:+ | -0.33 | -10.19 | 2.44E-23 | Response to tocilizumab in rheumatoid arthritis |
| BRCA | cis | rs4765219 | 1 | rs11057394 | chr12:124407676 | DNAH10 | chr12:124247042-124420265:+ | 0.25 | 6.43 | 1.87E-10 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs7953704 | 1 | rs11057654 | chr12:122608636 | LRRC43 | chr12:122652266-122688017:+ | -0.17 | -4.78 | 2.03E-6 | Urate levels |
| BRCA | cis | rs7953704 | 1 | rs11057905 | chr12:122609131 | LRRC43 | chr12:122652266-122688017:+ | -0.18 | -4.9 | 1.09E-6 | Urate levels |
| BRCA | cis | rs7953704 | 1 | rs11059094 | chr12:122606837 | LRRC43 | chr12:122652266-122688017:+ | -0.17 | -4.74 | 2.47E-6 | Urate levels |
| BRCA | cis | rs7953704 | 1 | rs11061602 | chr12:122615964 | LRRC43 | chr12:122652266-122688017:+ | 0.16 | 4.52 | 6.77E-6 | Urate levels |
| BRCA | cis | rs17030613 | 1 | rs1106287 | chr1:113242122 | ST7L | chr1:113066142-113162405:- | 0.59 | 13.24 | 3.65E-37 | Diastolic blood pressure;Blood pressure |
| BRCA | cis | rs10492096 | 1 | rs11064210 | chr12:6576721 | TAPBPL | chr12:6561177-6575601:+ | -0.16 | -3.81 | 0.000149 | Hip geometry |
| BRCA | cis | rs10492096 | 1 | rs11064218 | chr12:6586261 | TAPBPL | chr12:6561177-6575601:+ | -0.15 | -3.61 | 0.00032 | Hip geometry |
| BRCA | cis | rs11064881 | 1 | rs11064881 | chr12:120146925 | PRKAB1 | chr12:120105757-120119428:+ | -0.56 | -8.67 | 1.61E-17 | Ulcerative colitis;Inflammatory bowel disease |
| BRCA | cis | rs11190604 | 1 | rs1106565 | chr10:102211613 | SEC31B | chr10:102246403-102289636:- | -0.27 | -10.18 | 2.74E-23 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs7134594 | 1 | rs11067231 | chr12:109993603 | MMAB | chr12:109991523-110011358:- | -0.12 | -3.71 | 0.000222 | HDL cholesterol |
| BRCA | cis | rs7134594 | 1 | rs11067231 | chr12:109993603 | MYO1H | chr12:109826524-109886176:+ | 0.25 | 7.66 | 4.17E-14 | HDL cholesterol |
| BRCA | cis | rs3105593 | 1 | rs11070798 | chr15:50883263 | SPPL2A | chr15:50999739-51057910:- | 0.14 | 5.21 | 2.22E-7 | QT interval |
| BRCA | cis | rs2404602 | 1 | rs11072603 | chr15:76881138 | SCAPER | chr15:76640529-77197744:- | -0.19 | -6.77 | 2.16E-11 | Blood metabolite levels |